Inward rotating spiral waves in glycolysis.
نویسندگان
چکیده
We report on the first observation of inward rotating spiral waves (antispirals) in a biochemical reaction-diffusion system. Experiments are performed with extracts from yeast cells in an open spatial reactor. By increasing the protein concentration of the extract we observe a transition from outward to inward propagating waves of glycolytic activity. Numerical simulations with an allosteric model for the phosphofructokinase can reproduce these inward propagating waves over a wide range of parameters if the octameric structure of yeast phosphofructokinase is taken into account.
منابع مشابه
Crossflow instability of finite Bödewadt flows: Transients and spiral waves
The flow in an enclosed rotating cylinder with a stationary lower end wall is investigated numerically. For fast rotation rates, the flow in the interior is primarily in the azimuthal direction, with an angular momentum distribution very close to that corresponding to solid-body rotation for about the inner-half radius. The differential rotation sets up a large-scale circulation that is primari...
متن کاملTraveling waves in yeast extract and in cultures of Dictyostelium discoideum.
Biological self-organization was investigated in a biochemical and a cellular system: yeast extract and cultures of the slime mold Dictyostelium discoideum. In both systems traveling reaction-diffusion waves occur in response to oscillatory reactions. Glycolytic degradation of sugar in a yeast extract leads to the spontaneous formation of NADH and proton waves. Manipulation of the adenine nucle...
متن کاملInwardly rotating spiral waves in a reaction-diffusion system.
Almost 30 years have passed since the discovery of concentric (target) and spiral waves in the spatially extended Belousov-Zhabotinsky (BZ) reaction. Since then, rotating spirals and target waves have been observed in a variety of physical, chemical, and biological reaction-diffusion systems. All of these waves propagate out from the spiral center or pacemaker. We report observations of inwardl...
متن کاملTurbulent electrical activity at sharp-edged inexcitable obstacles in a model for human cardiac tissue.
Wave propagation around various geometric expansions, structures, and obstacles in cardiac tissue may result in the formation of unidirectional block of wave propagation and the onset of reentrant arrhythmias in the heart. Therefore, we investigated the conditions under which reentrant spiral waves can be generated by high-frequency stimulation at sharp-edged obstacles in the ten Tusscher-Noble...
متن کاملOne-Armed Spiral Waves in Galaxy Simulations with Counter-Rotating Stars One-Armed Spiral Waves in Galaxy Simulations with Counter-Rotating Stars
Motivated by observations of disk galaxies with counter-rotating stars, we have run two-dimensional, collisionless N−body simulations of disk galaxies with significant counter-rotating components. For all our simulations the initial value of Toomre’s stability parameter was Q = 1.1. The percentage of counter-rotating particles ranges from 25% to 50%. A stationary one-arm spiral wave is observed...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Biophysical journal
دوره 99 1 شماره
صفحات -
تاریخ انتشار 2010